It is through vaccination that lives of most people have been saved hence an indication that the concept is significant for modern medicine (Herbert 2016). However, development of the vaccine has only been possible for bacterial and viral diseases and very unsuccessful for diseases such as malaria and changes that are caused by protists. Fundamentally, development of the vaccine has been unevenly distributed and challenging across the world especially in developing countries that have concerns about their safety. A major reason behind this fact is that, the geopolitical reason, which is based on the fact that most developing nations fear that vaccination may be used for sterilization of population or infection of the population. To some extent, the fear of these developing countries may be valid as some health workers tend to ignore ethical concerns for the local people or make mistakes in the process of administering the vaccines hence living the life of people in danger. Similarly, some feel that vaccination has benefits to the doctors rather than the wider population (Herbert 2016).
On the other hand, vaccine development for chronic diseases such as HIV, Malaria, and Tuberculosis have been challenging due to the reason that they are co-endemic (Herbert 2016). The diseases are always dominant in infected individuals, and there is a possibility that they might go for weeks and months without being noticed. As biological reason, the infected people are unlikely to receive the diagnosis that increases the urgency of developing vaccine. Similarly, T cells are always relatively significant compared to antibodies when it comes to protection against the diseases. Understanding the immune responses to malaria, tuberculosis and HIV have also been a challenge. For instance, pathogenesis of illness which is caused by around five species of protist Plasmodium. It, therefore, makes the relative importance of T cells and B cells unclear in the process. Coming up with effective vaccine requires the better description of the immune responses to the pathogens (Herbert 2016).
Herbert, D. (2016). Protists. Retrieved from http://www.bio.miami.edu/tom/courses/bil160/bil160goods/11_protists.html